Chapter 18: Endocrine System
This video will provide a brief review of thyroid physiology and the laboratory tests used in the diagnosis of hypo- and hyperthyroidism before diving in to each entity that falls under the rubric “Autoimmune Thyroid Disease”: chronic lymphocytic (Hashimoto) thyroiditis, subacute granulomatous (de Quervain) thyroiditis, subacute lymphocytic (painless), Riedel (IgG4-mediated) thyroiditis and Graves disease.
This video works through the clinical findings, pathophysiology and diagnostic tests for diseases of the adrenal cortex: Cushing disease, hyperaldosteronism, adrenogenital syndromes and acute and chronic (Addison disease) adrenocortical insufficiency.
Diabetes is a HUGE topic! To create a more manageable "bite", this video includes a brief introduction to the pathogenesis of type I and type II diabetes, then focuses primarily on the pathophysiologic mechanisms that lead to the complications of chronic hyperglycemia: macro- and microvascular disease, polyneuropathy and blindness. We'll address advanced glycation end products, protein kinase C activation, oxidative stress/disturbances of the polyol pathway and the hexosamine pathway.